Gastrointestinal stromal tumor (GIST) ICD 8936/3

GIST882

(Synonyms: GIST-882 ; GIST 882)

HUSARC Accession Number: HU-21.2

KIT; Exon 13 ; p.Lys642Glu (c.1924A>G); Zygosity=Homozygous

More information about the models can be found in the datasheets.

If you are interested in a model, please contact the corresponding researcher directly (contact information can be found below and in the datasheet).

Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA, Demetri GD. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene. 2001 Aug 16;20(36):5054-8. DOI: 10.1038/sj.onc.1204704. PMID: 11526490.
Bauer S, Yu LK, Demetri GD, Fletcher JA. Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res. 2006 Sep 15;66(18):9153-61. DOI: 10.1158/0008-5472.CAN-06-0165. PMID: 16982758.
Mühlenberg T, Zhang Y, Wagner AJ, Grabellus F, Bradner J, Taeger G, Lang H, Taguchi T, Schuler M, Fletcher JA, Bauer S. Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. Cancer Res. 2009 Sep 1;69(17):6941-50. DOI: 10.1158/0008-5472.CAN-08-4004. Epub 2009 Aug 25. PMID: 19706776

Entry creation: 14.09.2021

Last entry update: 16.09.2021

Version number: #1